Efficacy of Afoxolaner in Six Cases of Canine Demodicosis

Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis

The efficacy of oral treatment with a chewable tablet containing afoxolaner 2.27% w/w (NexGard(®), Merial) administered orally was assessed in eight dogs diagnosed with generalised demodicosis and compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidectin (Advocate(®), Bayer). Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg...

Immunology and pathogenesis of canine demodicosis.

Demodex mites colonized the hair follicles and sebaceous glands of mammals millions of years ago and have remained relatively unchanged in this protected ecologic niche since then. The host immune system detects and tolerates their presence. Toll-like receptor-2 of keratinocytes has been demonstrated to recognize mite chitin and to elicit an innate immune response. The subsequent acquired immun...

Practical and update management of canine demodicosis

Canine demodicosis is a common parasitic skin disease in dogs. It can be classified into 2 types based on distribution of lesion; localized and generalized demodicosis. Localized demodicois was reported to be usually spontaneous remission, therefore, no treatment is needed. Generalized demodicosis, on the other hand, cannot heal spontaneously so miticidal therapy should be prescribed. However, ...

Therapeutic effect of dapson in six cases of Granuloma Annulare

Granuloma Annulare is an flammatory bening skin disease that may manifest different clinical features.the most common presentation or classic form of the disease is fleshcolor,annulare,grouped papules,disseminated forms are rare and responses to treatments are vnot satisfactory.various treatment modalities have been used for this disorder and different responses to treatments have been reported...

What Is New about Canine Demodicosis